Mid Level Rune Words - Diablo 2
This page contains a list of all the mid level Rune Words in Diablo 2 as well as a little bit of information about why they're on this list to begin with. Every Rune Word on this list is meant for characters who are level 30 to 50, if you'd like to check out my other lists of Rune Words then follow the links below.
List of Armor Rune Words
List of Helm Rune Words
List of Shield Rune Words
List of Weapon Rune Words
List of Intermediate Rune Words
Runeword: Insight
RalTirTalSol
Required Runes: 
Ral -- 
Tir -- 
Tal -- 
Sol
Level Req: 27
Other Req: Ladder Only
Slots: Polearms & Staves
Level 12-17 Meditation Aura When Equipped (varies)
+35% Faster Cast Rate
+200-260% Enhanced Damage (varies)
+9 To Minimum Damage
180-250% Bonus to Attack Rating (varies)
Adds 5-30 Fire Damage
+75 Poison Damage Over 5 Seconds
+1-6 To Critical Strike (varies)
+5 To All Attributes
+2 To Mana After Each Kill
23% Better Chance of Getting Magic Items
This weapon makes every Rune Word list whether it be beginner, intermediate or the best Rune Words in the game. The reason for this is because Insight comes with Meditation Aura which gives you insanely good mana regeneration. When put into a Polearm and equipped onto an Act 2 Mercenary you'll share the Meditation Aura with him. Extra tip: Use an Ethereal Polearm as it can't break when your Mercenary is using it, you'll be able to boost his damage this way!
Runeword: White
DolIo
Required Runes: 
Dol -- 
Io
Level Req: 35
Other Req: N/A
Slots: Wands Only
+3 to Poison and Bone Skills (Necromancer Only)
+20% Faster Cast Rate
+2 to Bone Spear (Necromancer Only)
+4 to Skeleton Mastery (Necromancer Only)
+3 to Bone Armor (Necromancer Only)
Hit causes monster to flee 25%
+10 to Vitality
+13 to Mana
Magic Damage Reduced by 4
White is a powerful Necromancer only Rune Word which is easy to make. You can find plenty of Wands on Akara in Act 1 Normal difficulty or Drognan in Act 2 if you need one with two open Sockets.
Runeword: Splendor
EthLum
Required Runes: 
Eth -- 
Lum
Level Req: 37
Other Req: N/A
Slots: Shield
+1 To All Skills
+10% Faster Cast Rate
+20% Faster Block Rate
+60-100% Enhanced Defense (varies)
+10 To Energy
Regenerate Mana 15%
50% Extra Gold From Monsters
20% Better Chance of Getting Magic Items
+3 To Light Radius
I often call this Rune Word the poor man's Spirit. It provides you +1 to Skills instead of Spirits +2 and it costs 2 High Runes instead of four. Thanks to it only costing two runes you can easily find a shield to put it into during Normal or Nightmare difficulty.
Runeword: Smoke
NefLum
Required Runes: 
Nef -- Lum
Level Req: 37
Other Req: N/A
Slots: Chest Armor
+20% Faster Hit Recovery
+75% Enhanced Defense
+280 Defense vs. Missiles
+10 to Energy
All Resistances +50
-1 to Light Radius
Level 6 Weaken (18 charges)
This armor Rune Word made the list because it provides exceptional All Resist for the level that it is. You can easily find a piece of armor with 2 open Sockets in Nightmare to create this Rune Word and it'll carry you all the way into Hell. Melee users who want a Rune Word that provides more damage than protection should check out Lionheart.
Runeword: Melody
ShaelKoNef
Required Runes: 
Shael -- 
Ko -- Nef
Level Req: 39
Other Req: N/A
Slots: Missile Weapons Only (Bows & Crossbows)
+3 To Bow and Crossbow Skills (Amazon Only)
+20% Increased Attack Speed
+50% Enhanced Damage
+300% Damage To Undead
+3 To Slow Missiles (Amazon Only)
+3 To Dodge (Amazon Only)
+3 To Critical Strike (Amazon Only)
Knockback
+10 To Dexterity
Melody is arguably the best mid level Missile weapon Rune Word in the game and one of the high end Rune Words some Bowzon's use when on a budget. What it lacks in raw Enhanced Damage it makes up for in utility and skill bonuses.
Runeword: Obedience
HelKoThulEthFal
Required Runes: 
Hel -- Ko -- 
Thul -- Eth -- 
Fal
Level Req: 41
Other Req: Ladder Only
Slots: Polearms Only
30% Chance To Cast Level 21 Enchant When You Kill An Enemy
+40% Faster Hit Recovery
+370% Enhanced Damage
-25% Target Defense
Adds 3-14 Cold Damage (3 Seconds Duration,Normal)
-25% To Enemy Fire Resistance
40% Chance of Crushing Blow
+200-300 Defense (varies)
+10 To Strength
+10 To Dexterity
All Resistances +20-30 (varies)
Requirements -20%
For its level range this weapon has an insane amount of Enhanced Damage paired with Crushing Blow. What's even better is it comes with a chance to proc Enchant which will boost your DPS even more.
Runeword: Lionheart
HelLumFal
Required Runes: Hel -- Lum -- Fal
Level Req: 41
Other Req: N/A
Slots: Chest Armor
+20% Enhanced Damage
+25 To Strength
+15 To Dexterity
+20 To Vitality
+10 To Energy
+50 To Life
All Resistances +30
Requirements -15%
Often called the poor man's Fortitude, this Rune Word is one of a few items in the entire game that comes with +Enhanced Damage on a piece of armor. The stats on this armor only help Melee builds, Casters will want to make Smoke or whatever their class specific Rune Word armor is.
Runeword: Treachery
ShaelThulLem
Required Runes: Shael -- Thul -- 
Lem
Level Req: 43
Other Req: N/A
Slots: Chest Armor
5% Chance To Cast Level 15 Fade When Struck
25% Chance To Cast Level 15 Venom On Striking
+2 To Assassin Skills
+45% Increased Attack Speed
+20% Faster Hit Recovery
Cold Resist +30%
50% Extra Gold From Monsters
Assassin Class specific Rune Word.
Runeword: Enlightenment
PulRalSol
Required Runes: 
Pul -- Ral -- Sol
Level Req: 45
Other Req: N/A
Slots: Chest Armor
5% Chance To Cast Level 15 Blaze When Struck
5% Chance To Cast Level 15 Fire Ball On Striking
+2 To Sorceress Skill Levels
+1 To Warmth
+30% Enhanced Defense
Fire Resist +30%
Damage Reduced By 7
Sorceress Class specific Rune Word. The Skill Level bonuses pair with Warmth are nice but it is lacking in protection. I'd recommend a Smoke Rune Word if you want more protection.
Runeword: Stone
ShaelUmPulLum
Required Runes: Shael -- 
Um -- Pul -- Lum
Level Req: 47
Other Req: N/A
Slots: Chest Armor
+60% Faster Hit Recovery
+250-290% Enhanced Defense (varies)
+300 Defense Vs. Missile
+16 To Strength
+16 To Vitality
+10 To Energy
All Resistances +15
Level 16 Molten Boulder (80 Charges)
Level 16 Clay Golem (16 Charges)
This Rune Word is kind of like an upgraded Smoke Rune Word just with less All Resist.
Runeword: Bone
SolUmUm
Required Runes: Sol -- Um -- Um
Level Req: 47
Other Req: N/A
Slots: Chest Armor
15% Chance To Cast level 10 Bone Armor When Struck
15% Chance To Cast level 10 Bone Spear On Striking
+2 To Necromancer Skill Levels
+100-150 To Mana (varies)
All Resistances +30
Damage Reduced By 7
Necromancer Class specific armor. This is a really nice piece since it comes with high All Resist, Mana and + Skills.
Runeword: Prudence
MalTir
Required Runes: 
Mal -- Tir
Level Req: 49
Other Req: N/A
Slots: Chest Armor
+25% Faster Hit Recovery
+140-170% Enhanced Defense (varies)
All Resistances +25-35 (varies)
Damage Reduced by 3
Magic Damage Reduced by 17
+2 To Mana After Each Kill
+1 To Light Radius
Repairs 1 Durability In 4 Seconds
This is one of the only chest armors that you're able to ebug in the game and wear on your actual character without it breaking. If you're able to find an Ethereal piece of exceptional or elite armor while you're in this level range, Prudence is not a bad choice at all for a Rune Word. It makes one of the best twink Rune Words for this level range too due to it being ebugable.
Runeword: Rain
OrtMalIth
Required Runes: 
Ort -- Mal -- 
Ith
Level Req: 49
Other Req: N/A
Slots: Chest Armor
5% Chance To Cast Level 15 Cyclone Armor When Struck
5% Chance To Cast Level 15 Twister On Striking
+2 To Druid Skills
+100-150 To Mana (varies)
Lightning Resist +30%
Magic Damage Reduced By 7
15% Damage Taken Goes to Mana
Druid Class specific armor Rune Word. Much like the Necromancer Rune Word this one is quite good for its level range.
Runeword: Oath
ShaelPulMalLum
Required Runes: Shael -- Pul -- Mal -- Lum
Level Req: 49
Other Req: Ladder Only
Slots: Axes, Maces and Swords
Indestructible
30% Chance To Cast Level 20 Bone Spirit On Striking
+50% Increased Attack Speed
+210-340% Enhanced Damage (varies)
+75% Damage To Demons
+100 To Attack Rating Against Demons
Prevent Monster Heal
+10 To Energy
+10-15 Magic Absorb (varies)
Level 16 Heart of Wolverine (20 Charges)
Level 17 Iron Golem (14 Charges)
This is the first "end game" Weapon Rune Word that you're able to put into an Ethereal weapon and use on your character without worrying about it breaking.