Silence: Weapon Rune Word - Diablo 2
Silence is one of the most powerful Rune Words in the game when it comes to putting out good damage and still being versatile. While Silence will not be the highest damage dealing Rune Word in the entire game it makes up for its lack of damage in the other unique attributes that it offers. +2 to All Skills, Mana Stolen Per Hit, insanely high All Resist and more are what make this weapon desired by many players.
Typically I see people put Silence into an Ethereal weapona nd then give it to their Mercenary, either an Act 2 Mercenary or an Act 5 are the most common choices. If you're a class that primarily deals ranged damage Silence will help a lot with the "Hit Causes Monster to Flee" and "Hit Blinds Target" attributes. Both of these will help keep monsters away from you and give you more time to deal damage from a distance.
Keep in mind that all Rune Words you create will retain any pre-existing bonuses found on the item. If you find a 'Superior' piece of armor with +Enhanced Defense, a Superior Weapon with +Enhanced Damage or a Helm/Weapon that has +Skill bonuses for a certain class, all of these will remain on the final Rune Word that is created. It's also possible to 'ebug' a piece of Ethereal Armor that you find which will increase the Defense bonuses by 50%, check out my Ebugging Guide for more information.
Farming High Runes: Out of all locations in the game one stands above the rest for farming specifically High Runes, the Countess during Act 1. The Countess has a guaranteed chance to always drop a High Rune and can even drop more than one. Check out my The Countess Farming Guide for more information.
Required Runes: 
Dol -- 
Eld -- 
Hel -- 
Ist -- 
Tir -- 
Vex
Level Req: 55
Other Req: N/A
Slots: All Weapons
+2 to All Skills
+20% Increased Attack Speed
+20% Faster Hit Recovery
+200% Enhanced Damage
+75% Damage To Undead
+50 to Attack Rating Against Undead
11% Mana Stolen Per Hit
Hit Blinds Target +33
Hit Causes Monster to Flee 25%
All Resistances +75
+2 to Mana After Each Kill
30% Better Chance of Getting Magic Items
Requirements -20%
