Famine: Weapon Rune Word - Diablo 2
Famine is one of the least used Rune Words in the entire game because it... well sucks. The Rune Word doesn't fit into any build and the only benefits of the array of elemental damage on it are for Physical Immune enemies. Usually in those situations you won't be wailing on them with your melee weapons anyway and instead be using an ability that deals non-physical damage.
Basically, there is always something better or cheaper that you could make in place of Famine.
Keep in mind that all Rune Words you create will retain any pre-existing bonuses found on the item. If you find a 'Superior' piece of armor with +Enhanced Defense, a Superior Weapon with +Enhanced Damage or a Helm/Weapon that has +Skill bonuses for a certain class, all of these will remain on the final Rune Word that is created. It's also possible to 'ebug' a piece of Ethereal Armor that you find which will increase the Defense bonuses by 50%, check out my Ebugging Guide for more information.
Farming High Runes: Out of all locations in the game one stands above the rest for farming specifically High Runes, the Countess during Act 1. The Countess has a guaranteed chance to always drop a High Rune and can even drop more than one. Check out my The Countess Farming Guide for more information.
Required Runes: Fal -- Ohm -- Ort -- Jah
Level Req: 65
Other Req: N/A
Slots: Axes & Hammers
+30% Increased Attack Speed
+320-370% Enhanced Damage (varies)
Ignore Target's Defense
Adds 180-200 Magic Damage
Adds 50-200 Fire Damage
Adds 51-250 Lightning Damage
Adds 50-200 Cold Damage
12% Life Stolen Per Hit
Prevent Monster Heal
+10 To Strength